diff --git a/ext/openssl/ossl.h b/ext/openssl/ossl.h
index 22471d2085..d519c96cd6 100644
--- a/ext/openssl/ossl.h
+++ b/ext/openssl/ossl.h
@@ -74,6 +74,10 @@
 # include <openssl/provider.h>
 #endif
 
+#if OSSL_OPENSSL_PREREQ(3, 0, 0)
+# define OSSL_HAVE_IMMUTABLE_PKEY
+#endif
+
 /*
  * Common Module
  */
diff --git a/ext/openssl/ossl_pkey.c b/ext/openssl/ossl_pkey.c
index 0fed03332f..37c132ef2e 100644
--- a/ext/openssl/ossl_pkey.c
+++ b/ext/openssl/ossl_pkey.c
@@ -508,7 +508,7 @@ ossl_pkey_s_generate_key(int argc, VALUE *argv, VALUE self)
 void
 ossl_pkey_check_public_key(const EVP_PKEY *pkey)
 {
-#if OSSL_OPENSSL_PREREQ(3, 0, 0)
+#ifdef OSSL_HAVE_IMMUTABLE_PKEY
     if (EVP_PKEY_missing_parameters(pkey))
         ossl_raise(ePKeyError, "parameters missing");
 #else
diff --git a/ext/openssl/ossl_pkey.h b/ext/openssl/ossl_pkey.h
index 6778381210..24823e0f3e 100644
--- a/ext/openssl/ossl_pkey.h
+++ b/ext/openssl/ossl_pkey.h
@@ -105,7 +105,7 @@ static VALUE ossl_##_keytype##_get_##_name(VALUE self)			\
 	OSSL_PKEY_BN_DEF_GETTER0(_keytype, _type, a2,			\
 		_type##_get0_##_group(obj, NULL, &bn))
 
-#if !OSSL_OPENSSL_PREREQ(3, 0, 0)
+#ifndef OSSL_HAVE_IMMUTABLE_PKEY
 #define OSSL_PKEY_BN_DEF_SETTER3(_keytype, _type, _group, a1, a2, a3)	\
 /*									\
  *  call-seq:								\
diff --git a/ext/openssl/ossl_pkey_ec.c b/ext/openssl/ossl_pkey_ec.c
index 1d20f63e0c..a2b68cc1d1 100644
--- a/ext/openssl/ossl_pkey_ec.c
+++ b/ext/openssl/ossl_pkey_ec.c
@@ -246,7 +246,7 @@ ossl_ec_key_get_group(VALUE self)
 static VALUE
 ossl_ec_key_set_group(VALUE self, VALUE group_v)
 {
-#if OSSL_OPENSSL_PREREQ(3, 0, 0)
+#ifdef OSSL_HAVE_IMMUTABLE_PKEY
     rb_raise(ePKeyError, "pkeys are immutable on OpenSSL 3.0");
 #else
     EC_KEY *ec;
@@ -288,7 +288,7 @@ static VALUE ossl_ec_key_get_private_key(VALUE self)
  */
 static VALUE ossl_ec_key_set_private_key(VALUE self, VALUE private_key)
 {
-#if OSSL_OPENSSL_PREREQ(3, 0, 0)
+#ifdef OSSL_HAVE_IMMUTABLE_PKEY
     rb_raise(ePKeyError, "pkeys are immutable on OpenSSL 3.0");
 #else
     EC_KEY *ec;
@@ -339,7 +339,7 @@ static VALUE ossl_ec_key_get_public_key(VALUE self)
  */
 static VALUE ossl_ec_key_set_public_key(VALUE self, VALUE public_key)
 {
-#if OSSL_OPENSSL_PREREQ(3, 0, 0)
+#ifdef OSSL_HAVE_IMMUTABLE_PKEY
     rb_raise(ePKeyError, "pkeys are immutable on OpenSSL 3.0");
 #else
     EC_KEY *ec;
@@ -511,7 +511,7 @@ ossl_ec_key_to_der(VALUE self)
  */
 static VALUE ossl_ec_key_generate_key(VALUE self)
 {
-#if OSSL_OPENSSL_PREREQ(3, 0, 0)
+#ifdef OSSL_HAVE_IMMUTABLE_PKEY
     rb_raise(ePKeyError, "pkeys are immutable on OpenSSL 3.0");
 #else
     EC_KEY *ec;
@@ -1368,7 +1368,7 @@ static VALUE ossl_ec_point_make_affine(VALUE self)
     GetECPointGroup(self, group);
 
     rb_warn("OpenSSL::PKey::EC::Point#make_affine! is deprecated");
-#if !OSSL_OPENSSL_PREREQ(3, 0, 0) && !defined(OPENSSL_IS_AWSLC)
+#if !defined(OSSL_HAVE_IMMUTABLE_PKEY) && !defined(OPENSSL_IS_AWSLC)
     if (EC_POINT_make_affine(group, point, ossl_bn_ctx) != 1)
         ossl_raise(eEC_POINT, "EC_POINT_make_affine");
 #endif